Fanconi’s Syndrome

What is Fanconi's Syndrome?

This is an abnormality of the kidneys whereby the kidneys can not reabsorb and use certain products leading to excessive excretion in the urine and changes within the body as a result.

How does my dog get Fanconi's Syndrome?

This is a genetic condition found most commonly in Basenjis but also effecting other breeds (see below).  Rarely, Fanconi’s may develop as the result of the use of kidney damaging drugs such as gentamicin

How do I know if my dog has Fanconi's Syndrome?

Age at the first development of signs ranges from one year to eight years old.  The signs include an increase in water consumption, urination and concurrent weight loss.  The syndrome can progress to kidney failure.  Additional findings include muscle weakness and boney changes.  Your veterinarian will be the one to diagnose Fanconi’s Syndrome.  By doing blood and urine tests, Fanconi’s may be identified.  Rarely, special urine testing may be needed to confirm.  You may be suspect Fanconi’s with the above mentioned signs and the use of gentamicin.

What can I do about Fanconi's Syndrome?

If your dog is on gentamicin, it must be stopped and the damage to the kidneys.  In inherited cases, there is nothing to reverse the damage and thus the specific renal abnormalities are treated.  Each case is assessed and treated differently based upon the changes found.  The condition may progress rapidly or slowly to kidney failure.  Constant monitoring of kidney function is needed.

Is there anything I can do to prevent my dog from getting Fanconi's Syndrome?

Besides avoid the high risk breeds listed below, make sure your veterinarian avoids using drugs that are damaging to the kidneys.

Are there certain breeds that get Fanconi's Syndrome more often?

Basenji, Norwegian elkhound, Shetland sheepdog, Schnauzer.